PARPs and the DNA damage response.

  title={PARPs and the DNA damage response.},
  author={Fabricio G. Sousa and Renata Matuo and Daniel{\'e} Grazziotin Soares and Alexandre E Escargueil and Jo{\~a}o Antonio P{\^e}gas Henriques and Annette Kragh Larsen and Jenifer Saffi},
  volume={33 8},
Adenosine diphosphate (ADP)-ribosylation is an important posttranslational modification catalyzed by a variety of enzymes, including poly (ADP ribose) polymerases (PARPs), which use nicotinamide adenine dinucleotide (NAD(+)) as a substrate to synthesize and transfer ADP-ribose units to acceptor proteins. The PARP family members possess a variety of structural domains, span a wide range of functions and localize to various cellular compartments. Among the molecular actions attributed to PARPs… CONTINUE READING
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