PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription.

@article{Zhao2015PARP1AC,
  title={PARP1- and CTCF-Mediated Interactions between Active and Repressed Chromatin at the Lamina Promote Oscillating Transcription.},
  author={Honglei Zhao and Emmanouil G. Sifakis and Noriyuki Sumida and Llu{\'i}s Mill{\'a}n-Ari{\~n}o and Barbara A. Scholz and J. Peter Svensson and Xingqi Chen and Anna Lewandowska Ronnegren and Carolina Diettrich Mallet de Lima and Farzaneh Shahin Varnoosfaderani and Chengxi Shi and Olga Vladislavovna Loseva and Samer Yammine and Maria Israelsson and Li-Sophie Zhao Rathje and Bal{\'a}zs N{\'e}meti and Erik Fredlund and Thomas Helleday and Marta P. Imreh and Anita G{\"o}nd{\"o}r},
  journal={Molecular cell},
  year={2015},
  volume={59 6},
  pages={
          984-97
        }
}
Transcriptionally active and inactive chromatin domains tend to segregate into separate sub-nuclear compartments to maintain stable expression patterns. However, here we uncovered an inter-chromosomal network connecting active loci enriched in circadian genes to repressed lamina-associated domains (LADs). The interactome is regulated by PARP1 and its co-factor CTCF. They not only mediate chromatin fiber interactions but also promote the recruitment of circadian genes to the lamina… CONTINUE READING
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