PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation?

@article{Arnold2002PARPmediatedPA,
  title={PARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation?},
  author={Jenny Arnold and T. Grune},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2002},
  volume={24 11},
  pages={1060-5}
}
During the evolution of aerobic life, antioxidant defence systems developed that either directly prevent oxidative modifications of the cellular constituents or remove the modified components. An example of the latter is the proteasome, which removes cytosolic oxidised proteins. Recently, a novel mechanism of activation of the nuclear 20S proteasome was discovered: automodified poly-(ADP-ribose) polymerase-1 (PARP-1) activates the proteasome to facilitate selective degradation of oxidatively… CONTINUE READING

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