PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

  title={PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.},
  author={Helen E Bryant and Eva Petermann and Niklas Schultz and Ann-Sofie Jemth and Olga Loseva and Natalia Issaeva and Fredrik Johansson and Serena Fernandez and Peter McGlynn and Thomas Helleday},
  journal={The EMBO journal},
  volume={28 17},
If replication forks are perturbed, a multifaceted response including several DNA repair and cell cycle checkpoint pathways is activated to ensure faithful DNA replication. Here, we show that poly(ADP-ribose) polymerase 1 (PARP1) binds to and is activated by stalled replication forks that contain small gaps. PARP1 collaborates with Mre11 to promote replication fork restart after release from replication blocks, most likely by recruiting Mre11 to the replication fork to promote resection of DNA… CONTINUE READING
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