PARP inhibitors: mechanism of action and their potential role in the prevention and treatment of cancer.

Abstract

The use of poly(ADP-ribose) polymerase (PARP) inhibitors provided proof-of-concept for a synthetic lethal anti-cancer strategy as a result of their efficacy and favourable toxicity profile in BRCA1/2 mutation carriers. Efforts are underway to identify a broader group of patients with genomic susceptibility that may benefit from these agents. In an endeavour… (More)
DOI: 10.2165/11635510-000000000-00000

Topics

Cite this paper

@article{Basu2012PARPIM, title={PARP inhibitors: mechanism of action and their potential role in the prevention and treatment of cancer.}, author={Bristi Basu and S. Sandhu and J de Bono}, journal={Drugs}, year={2012}, volume={72 12}, pages={1579-90} }