PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression

@inproceedings{Mariano2015PARPIA,
  title={PARP inhibitor ABT-888 affects response of MDA-MB-231 cells to doxorubicin treatment, targeting Snail expression},
  author={Germano Mariano and Maria Rosaria Ricciardi and Daniela Trisciuoglio and Michele Zampieri and Fabio Ciccarone and T Guastafierro and Roberta Calabrese and Elisabetta Valentini and Agostino Tafuri and D Del Bufalo and Paola Caiafa and Anna Reale},
  booktitle={Oncotarget},
  year={2015}
}
To overcome cancer cells resistance to pharmacological therapy, the development of new therapeutic approaches becomes urgent. For this purpose, the use of poly(ADP-ribose) polymerase (PARP) inhibitors in combination with other cytotoxic agents could represent an efficacious strategy. Poly(ADP-ribosyl)ation (PARylation) is a post-translational modification that plays a well characterized role in the cellular decisions of life and death. Recent findings indicate that PARP-1 may control the… CONTINUE READING
8 Citations
76 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 76 references

Similar Papers

Loading similar papers…