PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers.

@article{Carden2010PARPIT,
  title={PARP inhibition: targeting the Achilles' heel of DNA repair to treat germline and sporadic ovarian cancers.},
  author={Craig P. Carden and Timothy A Yap and Stanley B. Kaye},
  journal={Current opinion in oncology},
  year={2010},
  volume={22 5},
  pages={473-80}
}
PURPOSE OF REVIEW Ovarian cancer remains the gynaecological malignancy with the highest mortality in the Western world. The strategy of identifying biologically distinct subgroups of ovarian cancer by means of clinical characteristics, histology and molecular profiling is an exciting prospect in personalizing and improving therapy for ovarian cancer. RECENT FINDINGS Preclinical recognition that BRCA1 and BRCA2-associated tumours are very sensitive to inhibition of poly-ADP ribose polymerase… CONTINUE READING