PARP expression in germ cell tumours

  title={PARP expression in germ cell tumours},
  author={M. Mego and Z. {\vC}ierna and D. Světlovsk{\'a} and D. Ma{\vc}{\'a}k and K. Mach{\'a}lekov{\'a} and V. Miskovska and M. Chovanec and V. Usakova and J. Obertova and P. Bab{\'a}l and J. Mardiak},
  journal={Journal of Clinical Pathology},
  pages={607 - 612}
  • M. Mego, Z. Čierna, +8 authors J. Mardiak
  • Published 2013
  • Medicine
  • Journal of Clinical Pathology
  • Background Poly(ADP-ribose)polymerase (PARP) inhibitors represent a new class of promising drugs in anticancer therapy. Aims To evaluate PARP expression in testicular germ cell tumours (GCTs) and to correlate expression patterns with clinicopathological variables. Methods In this translational study, tumour specimens from 124 patients with GCTs (114 patients with testicular primary tumours and 10 with extragonadal GCTs) were identified. PARP expression was detected by immunohistochemistry using… CONTINUE READING
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    Testicular germ-cell cancer
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