PARP Inhibitors in BRCA Gene-Mutated Ovarian Cancer and Beyond

  title={PARP Inhibitors in BRCA Gene-Mutated Ovarian Cancer and Beyond},
  author={S. Banerjee and S. Kaye},
  journal={Current Oncology Reports},
  • S. Banerjee, S. Kaye
  • Published 2011
  • Medicine
  • Current Oncology Reports
  • Poly(ADP-ribose)polymerase (PARP) inhibitors are showing considerable promise for the treatment of BRCA mutation–associated ovarian and breast cancer. This approach exploits a synthetic lethal strategy to target the specific DNA repair pathway in cancers that harbor mutations in the BRCA1 or BRCA2 genes. Accumulating evidence suggests that PARP inhibitors may have a wider application in the treatment of sporadic, high-grade serous ovarian cancers and other cancers including endometrial cancer… CONTINUE READING

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