PARP Inhibitors: The Cornerstone of DNA Repair-Targeted Therapies.

  title={PARP Inhibitors: The Cornerstone of DNA Repair-Targeted Therapies.},
  author={Jaydira del Rivero and Elise C. Kohn},
  volume={31 4},
The activity and therapeutic licensing of poly(ADP-ribose) polymerase (PARP) inhibitors is the culmination of 50 years of research. However, the biology, mechanisms of action, adequate treatment combinations, and targeted populations for these agents need to be explored further. PARP activity is essential for the repair of single-strand DNA breaks via the base excision repair pathway. This pathway is the default repair pathway in cells with deficient high-fidelity double-strand break homologous… CONTINUE READING
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