PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA*

@article{Loseva2010PARP3IA,
  title={PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA*},
  author={O. I. Loseva and Ann-Sofie Jemth and Helen E. Bryant and Herwig Sch{\"u}ler and Lari Lehti{\"o} and Tobias Karlberg and Thomas Helleday},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={285},
  pages={8054 - 8060}
}
The PARP-3 protein is closely related to the PARP-1 and PARP-2 proteins, which are involved in DNA repair and genome maintenance. Here, we characterized the biochemical properties of human PARP-3. PARP-3 is able to ADP-ribosylate itself as well as histone H1, a previously unknown substrate for PARP-3. PARP-3 is not activated upon binding to DNA and is a mono-ADP-ribosylase, in contrast to PARP-1 and PARP-2. PARP-3 interacts with PARP-1 and activates PARP-1 in the absence of DNA, resulting in… Expand
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TLDR
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TLDR
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