PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation.

@article{Liang2013PARP2RC,
  title={PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation.},
  author={Ya-Chen Liang and Chiao-Yu Hsu and Ya-Li Yao and Wen-Ming Yang},
  journal={Biochemical and biophysical research communications},
  year={2013},
  volume={431 1},
  pages={
          58-64
        }
}
Poly(ADP-ribose) polymerase-2 (PARP-2) catalyzes poly(ADP-ribosyl)ation (PARylation) and regulates numerous nuclear processes, including transcription. Depletion of PARP-2 alters the activity of transcription factors and global gene expression. However, the molecular action of how PARP-2 controls the transcription of target promoters remains unclear. Here we report that PARP-2 possesses transcriptional repression activity independently of its enzymatic activity. PARP-2 interacts and recruits… CONTINUE READING

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