PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation*

@article{Mehrotra2010PARP14FA,
  title={PARP-14 Functions as a Transcriptional Switch for Stat6-dependent Gene Activation*},
  author={P. Mehrotra and J. Riley and R. Patel and F. Li and Le’erin Voss and S. Goenka},
  journal={The Journal of Biological Chemistry},
  year={2010},
  volume={286},
  pages={1767 - 1776}
}
  • P. Mehrotra, J. Riley, +3 authors S. Goenka
  • Published 2010
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • A subset of poly ADP-ribose polymerases (PARP) that also contain macro domains regulate transcription. One such macro PARP, PARP-14 alters interleukin 4 (IL-4) and Stat6-dependent transcription. Stat6, activated by IL-4 plays an important role in T helper cell immunity and B cell responses. Here we define the mechanism by which PARP-14 regulates Stat6-activated transcription. Under non-stimulating conditions, PARP-14 recruits HDAC 2 and 3 to IL-4 responsive promoters. In the presence of IL-4… CONTINUE READING
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