PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases

@article{Martire2015PARP1II,
  title={PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases},
  author={Sara Martire and Luciana Mosca and Maria d’Erme},
  journal={Mechanisms of Ageing and Development},
  year={2015},
  volume={146–148},
  pages={53-64}
}
DNA damage is the prime activator of the enzyme poly(ADP-ribose)polymerase1 (PARP-1) whose overactivation has been proven to be associated with the pathogenesis of numerous central nervous system disorders, such as ischemia, neuroinflammation, and neurodegenerative diseases. Under oxidative stress conditions PARP-1 activity increases, leading to an accumulation of ADP-ribose polymers and NAD(+) depletion, that induces energy crisis and finally cell death. This review aims to explain the… CONTINUE READING
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