PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice.

@article{Dharwal2018PARP1IA,
  title={PARP-1 inhibition ameliorates elastase induced lung inflammation and emphysema in mice.},
  author={Vivek Dharwal and Amarjit S Naura},
  journal={Biochemical pharmacology},
  year={2018},
  volume={150},
  pages={
          24-34
        }
}
COPD is associated with high morbidity and mortality and no effective treatment is available till date. We have previously reported that PARP-1 plays an important role in the establishment of airway inflammation associated with asthma and ALI. In the present work, we have evaluated the beneficial effects of PARP-1 inhibition on COPD pathogenesis utilizing elastase induced mouse model of the disease. Our data show that PARP-1 inhibition by olaparib significantly reduced the elastase-induced… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 99 REFERENCES

Reciprocal regulation of iNOS and PARP-1 during allergen-induced eosinophilia.

  • The European respiratory journal
  • 2008
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

HYDAMTIQ

L. Lucarini, M. Durante, +6 authors G. Mannaioni
  • a selective PARP-1 inhibitor, improves bleomycin-induced lung fibrosis by dampening the TGF-beta/SMAD signalling pathway, J. Cell Mol. Med. 21
  • 2017

Impact of air quality guidelines on COPD sufferers

  • International journal of chronic obstructive pulmonary disease
  • 2016

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