PARP-1--a Perpetrator of Apoptotic Cell Death?

@article{Chiarugi2002PARP1aPO,
  title={PARP-1--a Perpetrator of Apoptotic Cell Death?},
  author={Alberto Chiarugi and Michael A. Moskowitz},
  journal={Science},
  year={2002},
  volume={297},
  pages={200 - 201}
}
The caspase-dependent pathway of programmed cell death has been well documented. In their Perspective, Chiarugi and Moskowitz report on new findings ( Yu et al .) that reveal a caspase-independent pathway of apoptosis driven by the nuclear enzyme PARP-1. 
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RETRACTED ARTICLE: Advanced oxidation protein products induce chondrocyte death through a redox-dependent, poly (ADP-ribose) polymerase-1-mediated pathway
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Results in vitro demonstrated that AOPPs induced cell death in human chondrocyte through a redox-dependent pathway, including RAGE-mediated, NADPH oxidase-dependent ROS generation, and poly (ADP-ribose) polymerase-1 (PARP-1) activation. Expand
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