PARL: The mitochondrial rhomboid protease.

  title={PARL: The mitochondrial rhomboid protease.},
  author={Marco Spinazzi and Bart De Strooper},
  journal={Seminars in cell & developmental biology},
The rhomboid family comprises evolutionary conserved intramembrane proteases involved in a wide spectrum of biologically relevant activities. A mitochondrion-localized rhomboid, called PARL in mammals, and conserved in yeast and Drosophila as RBD1/PCP1 and rho-7, respectively, plays an indispensable role in cell homeostasis as illustrated by the severe phenotypes caused by its genetic ablation in the various investigated species. Although several substrates of PARL have been proposed to explain… CONTINUE READING
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