PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease

@article{Beecham2015PARK10IA,
  title={PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease},
  author={G. Beecham and D. Dickson and W. Scott and E. Martin and G. Schellenberg and K. Nuytemans and E. Larson and J. Buxbaum and J. Trojanowski and V. V. Van Deerlin and H. Hurtig and D. Mash and T. Beach and J. Troncoso and O. Pletnikov{\'a} and M. Frosch and B. Ghetti and T. Foroud and L. Honig and K. Marder and J. Vonsattel and S. Goldman and H. Vinters and O. Ross and Z. Wszolek and L. Wang and D. Dykxhoorn and M. Pericak-Vance and T. Montine and J. Leverenz and T. Dawson and J. Vance},
  journal={Neurology},
  year={2015},
  volume={84},
  pages={972 - 980}
}
  • G. Beecham, D. Dickson, +29 authors J. Vance
  • Published 2015
  • Biology, Medicine
  • Neurology
  • Objective: To minimize pathologic heterogeneity in genetic studies of Parkinson disease (PD), the Autopsy-Confirmed Parkinson Disease Genetics Consortium conducted a genome-wide association study using both patients with neuropathologically confirmed PD and controls. Methods: Four hundred eighty-four cases and 1,145 controls met neuropathologic diagnostic criteria, were genotyped, and then imputed to 3,922,209 variants for genome-wide association study analysis. Results: A small region on… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease
    • 1,526
    • PDF
    Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra
    • 48
    Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.
    • 66
    Age at onset in two common neurodegenerative diseases is genetically controlled.
    • 317
    • PDF
    A Two-Stage Meta-Analysis Identifies Several New Loci for Parkinson's Disease
    • 223
    • PDF