• DOI:10.1212/WNL.0000000000001332
Corpus ID: 9166213

PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease

@article{Beecham2015PARK10IA,
  title={PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease},
  author={G. Beecham and D. Dickson and W. Scott and E. Martin and G. Schellenberg and K. Nuytemans and E. Larson and J. Buxbaum and J. Trojanowski and V. V. Van Deerlin and H. Hurtig and D. Mash and T. Beach and J. Troncoso and O. Pletnikov{\'a} and M. Frosch and B. Ghetti and T. Foroud and L. Honig and K. Marder and J. Vonsattel and S. Goldman and H. Vinters and O. Ross and Z. Wszolek and L. Wang and D. Dykxhoorn and M. Pericak-Vance and T. Montine and J. Leverenz and T. Dawson and J. Vance},
  journal={Neurology},
  year={2015},
  volume={84},
  pages={972 - 980}
}

G. Beecham, D. Dickson, +29 authors J. Vance

Published 2015

Biology, Medicine

Neurology

Objective: To minimize pathologic heterogeneity in genetic studies of Parkinson disease (PD), the Autopsy-Confirmed Parkinson Disease Genetics Consortium conducted a genome-wide association study using both patients with neuropathologically confirmed PD and controls. Methods: Four hundred eighty-four cases and 1,145 controls met neuropathologic diagnostic criteria, were genotyped, and then imputed to 3,922,209 variants for genome-wide association study analysis. Results: A small region on… CONTINUE READING

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