PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

@article{Shin2011PARISR,
  title={PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease},
  author={Joo-ho Shin and Han Seok Ko and Hochul Kang and Yunjong Dae Lee and Yun-il Lee and Olga Pletinkova and Juan C. Troconso and Valina L Dawson and Ted M Dawson},
  journal={Cell},
  year={2011},
  volume={144},
  pages={689-702}
}
A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new parkin interacting substrate, PARIS (ZNF746), whose levels are regulated by the ubiquitin proteasome system via binding to and ubiquitination by the E3 ubiquitin ligase, parkin. PARIS is a KRAB and zinc finger protein that accumulates in models of parkin inactivation and in human PD brain. PARIS represses the expression of the transcriptional coactivator, PGC-1α and the… CONTINUE READING
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