author={Robert D Goldney},
  journal={Medical Journal of Australia},
  • R. Goldney
  • Published 1 January 1977
  • Psychology
  • Medical Journal of Australia
This case report demonstrates that paradoxical reactions to the benzodiazepine class of minor tranquillizer can occur, and that lorazepam, a new derivative, is not free from this effect. It also lends support to the hypothesis that such reactions may be precipitated by a frustrating stimulus, and this has clinical relevance in that such precipitants may well be similar to those situations producing anxiety for which the drug had been prescribed. 
10 Citations

Paradoxical Excitation Following Intravenous Lorazepam Administration for Alcohol Withdrawal - A Case Presentation and Literature Review.

This rare presentation of paradoxical excitation with the use of lorazepam in a 50-year-old male being treated for alcohol withdrawal is reported and the underlying pathophysiology, pharmacology, and current literature are reviewed.

Disinhibitory reactions to benzodiazepines: a review.

  • P. van der BijlJ. Roelofse
  • Psychology
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
  • 1991

Reactions to Benzodiazepines

The emergence of hostile reactions may involve increased verbal hostility and even physical assault. Often this behavior appears to be triggered by some frustrating stimulus before the patient

Tranquilizer und Hypnotika: Grundlagen und Therapie

Wohl auf keinem anderen Gebiet der Psychopharmakologie machen sich semantische Probleme so storend bemerkbar wie bei den Psychopharmaka, die je nach Autor und Gelegenheit als Tranquilizer, „Minor

Benzodiazepine behavioral side effects: review and implications for individuals with mental retardation.

Behavioral side effects associated with benzodiazepines (such as clonazepam, diazepam, and lorazepam) are an easily overlooked and underrecognized problem with individuals who have mental retardation

The Effects of Non-Prescribing of Anxiolytics in General Practice: II. Factors Associated with Outcome

Outcome according to the PSE was significantly associated with: worse measures of psychiatric state and of social functioning at initial consultation and one month later; and with persistent anxious or depressed mood during the follow-up period; but not with life events.

Neuropsychiatric Adverse Drug Reactions: Passive Reports to Health and Welfare Canada's Adverse Drug Reaction Database (1965-Present)

  • S. PattenE. Love
  • Medicine, Psychology
    International journal of psychiatry in medicine
  • 1994
The purpose of this article is to summarize the Psychiatric ADRs reported to this database since 1965, and find areas of apparent contradiction between the contents of the database and the clinical literature.

An Evidence-Based Approach to the Management of Agitation in the Geriatric Patient

The definition, diagnosis, etiology, and initial management strategy of agitation will be delineated and the aim of the article is to provide a practical overview and a clinical perspective on this topic.

Standard therapies for acute agitation.