PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways.

@article{Cenac2004PAR2AA,
  title={PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways.},
  author={Nicolas Cenac and Alex C. Chin and Rafael Garcia-Villar and Christel Salvador-Cartier and Laurent P. Ferrier and Nathalie Vergnolle and Andre G Buret and Jean Fioramonti and Lionel Bu{\'e}no},
  journal={The Journal of physiology},
  year={2004},
  volume={558 Pt 3},
  pages={913-25}
}
Activation of colonic proteinase-activated receptor-2 (PAR(2)) caused inflammation and increased mucosal permeability in mouse colon. The present study was aimed at characterizing the possible links between these two phenomena. We evaluated the effects of intracolonic infusion of PAR(2)-activating peptide, SLIGRL, on colonic paracellular permeability and inflammation at two different doses, 5 and 100 microg per mouse, in an attempt to discriminate between both PAR(2)-mediated effects. We… CONTINUE READING
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