PAR1 cleavage and signaling in response to activated protein C and thrombin.

@article{Ludeman2005PAR1CA,
  title={PAR1 cleavage and signaling in response to activated protein C and thrombin.},
  author={Matthew J. Ludeman and Hiroshi Kataoka and Yoga Srinivasan and Naomi L. Esmon and Charles T. Esmon and Shaun R Coughlin},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 13},
  pages={13122-8}
}
Activated protein C (APC), a natural anticoagulant protease, can trigger cellular responses via protease-activated receptor-1 (PAR1), a G protein-coupled receptor for thrombin. Whether this phenomenon contributes to the physiological effects of APC is unknown. Toward answering this question, we compared the kinetics of PAR1 cleavage on endothelial cells by APC versus thrombin. APC did cleave PAR1 on the endothelial surface, and antibodies to the endothelial protein C receptor inhibited such… CONTINUE READING

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