PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling

  title={PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling},
  author={T Q Sun and Bingwei Lu and Jianhua Feng and Christoph Reinhard and Yuh Nung Jan and Wendy J. Fantl and Lewis T. Williams},
  journal={Nature Cell Biology},
Wnt signalling regulates β-catenin-dependent developmental processes through the Dishevelled protein (Dsh). Dsh regulates two distinct pathways, one mediated by β-catenin and the other by Jun kinase (JNK). We have purified a Dsh-associated kinase from Drosophila that encodes a homologue of Caenorhabditis elegans PAR-1, a known determinant of polarity during asymmetric cell divisions. Treating cells with Wnt increases endogenous PAR-1 activity coincident with Dsh phosphorylation. PAR-1… 

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