PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C. elegans

@inproceedings{Svensk2013PAQR2RF,
  title={PAQR-2 Regulates Fatty Acid Desaturation during Cold Adaptation in C. elegans},
  author={Emma Svensk and Marcus St{\aa}hlman and Carl-Henrik Andersson and Maja Johansson and Jan Bor{\'e}n and Marc Pilon},
  booktitle={PLoS genetics},
  year={2013}
}
C. elegans PAQR-2 is homologous to the insulin-sensitizing adiponectin receptors in mammals, and essential for adaptation to growth at 15°C, a low but usually acceptable temperature for this organism. By screening for novel paqr-2 suppressors, we identified mutations in genes involved in phosphatidylcholine synthesis (cept-1, pcyt-1 and sams-1) and fatty acid metabolism (ech-7, hacd-1, mdt-15, nhr-49 and sbp-1). We then show genetic evidence that paqr-2, phosphatidylcholines, sbp-1 and Δ9… CONTINUE READING
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