PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia

@article{Beyaert2013PAOPAAP,
  title={PAOPA, a potent dopamine D2 receptor allosteric modulator, prevents and reverses behavioral and biochemical abnormalities in an amphetamine-sensitized preclinical animal model of schizophrenia},
  author={Michael G. R. Beyaert and R. Daya and B. Dyck and R. Johnson and R. Mishra},
  journal={European Neuropsychopharmacology},
  year={2013},
  volume={23},
  pages={253-262}
}
  • Michael G. R. Beyaert, R. Daya, +2 authors R. Mishra
  • Published 2013
  • Psychology, Medicine
  • European Neuropsychopharmacology
  • Allosteric modulators are emerging as new therapeutics for the treatment of psychiatric illnesses, such as schizophrenia. Conventional antipsychotic drugs are typically dopamine D2 receptor antagonists that compete with endogenous dopamine at the orthosteric site, and block excessive dopamine neurotransmission in the brain. However, they are unable to treat all symptoms of schizophrenia and often cause adverse motor and metabolic side effects. The binding profile of allosteric modulators… CONTINUE READING
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    References

    SHOWING 1-10 OF 59 REFERENCES
    Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia
    • 173
    • PDF
    Third generation antipsychotic drugs: partial agonism or receptor functional selectivity?
    • 201
    The mechanism of action of novel antipsychotic drugs.
    • H. Meltzer
    • Psychology, Medicine
    • Schizophrenia bulletin
    • 1991
    • 366
    • PDF
    Centrally Active Allosteric Potentiators of the M4 Muscarinic Acetylcholine Receptor Reverse Amphetamine-Induced Hyperlocomotor Activity in Rats
    • 154
    • PDF
    Biphenyl-indanone A, a Positive Allosteric Modulator of the Metabotropic Glutamate Receptor Subtype 2, Has Antipsychotic- and Anxiolytic-Like Effects in Mice
    • 150
    • PDF
    Dopamine D2High receptors measured ex vivo are elevated in amphetamine‐sensitized animals
    • 34
    Galantamine Enhances Dopaminergic Neurotransmission In Vivo Via Allosteric Potentiation of Nicotinic Acetylcholine Receptors
    • 113
    • PDF
    A Novel α5GABAAR-Positive Allosteric Modulator Reverses Hyperactivation of the Dopamine System in the MAM Model of Schizophrenia
    • 107
    • PDF