PANVAC-VF: poxviral-based vaccine therapy targeting CEA and MUC1 in carcinoma.

  title={PANVAC-VF: poxviral-based vaccine therapy targeting CEA and MUC1 in carcinoma.},
  author={Ravi Amrit Madan and Philip M. Arlen and James L. Gulley},
  journal={Expert opinion on biological therapy},
  volume={7 4},
PANVAC is a cancer vaccine therapy delivered through two viral vectors--recombinant vaccinia and recombinant fowlpox--which are given sequentially. Both vectors contain transgenes for the tumor-associated antigens epithelial mucin 1 and carcinoembryonic antigen, which are altered or overexpressed in most carcinomas. The vectors also contain transgenes for three human T cell costimulatory molecules required to enhance immune response: B7.1, intracellular adhesion molecule-1 and leukocyte… CONTINUE READING


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