PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK.

@article{Chen2007PAN811PN,
  title={PAN-811 provides neuroprotection against glutamate toxicity by suppressing activation of JNK and p38 MAPK.},
  author={R Chen and X. C. Lu and Changping Yao and Zhilin Liao and Zhi-Gang Jiang and Hans H Wei and Hossein A. Ghanbari and Frank C. Tortella and Jitendra R. Dave},
  journal={Neuroscience letters},
  year={2007},
  volume={422 1},
  pages={64-7}
}
In an earlier study, we demonstrated that PAN-811 (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), a novel neuroprotectant, provides protection against glutamate, staurosporine, veratridine, or hypoxia/hypoglycemia toxicities in primary cortical neuronal cultures by upregulating Bcl-2 expression [R.-W. Chen, C. Yao, X.C. Lu, Z.-G. Jiang, R. Whipple, Z. Liao, H.A. Ghanbari, B. Almassian, F.C. Tortella, J.R. Dave. PAN-811 (3-aminopyridine-2-carboxaldehyde thiosemicarbazone), a novel… CONTINUE READING
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