PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization.

@article{Igarta2018PAMAMDA,
  title={PAMAM dendrimers as a carbamazepine delivery system for neurodegenerative diseases: A biophysical and nanotoxicological characterization.},
  author={Daniela Edith Igart{\'u}a and Carolina Soledad Martinez and C Facundo Temprana and Silvia Del Valle Alonso and Mar{\'i}a Jimena Prieto},
  journal={International journal of pharmaceutics},
  year={2018},
  volume={544 1},
  pages={
          191-202
        }
}
Carbamazepine (CBZ) is an antiepileptic drug, which also could be used in the treatment of neurodegenerative diseases, such as the Alzheimer's disease. However, its use has been limited due to its low solubility, inefficient pharmacokinetic profiles, and multiple side effects. PAMAM dendrimers, ethylenediamine core, generation 4.0 (amine terminal groups) and 4.5 (carboxylate terminal groups) (DG4.0 and DG4.5 respectively) are polymers that can increase drug solubility through complexation. Thus… CONTINUE READING
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