PAL31, a novel nuclear protein, expressed in the developing brain.

  title={PAL31, a novel nuclear protein, expressed in the developing brain.},
  author={Hideki Mutai and Yuka Toyoshima and Weiyong Sun and Naka Hattori and Shinya Tanaka and Kunio Shiota},
  journal={Biochemical and biophysical research communications},
  volume={274 2},
We cloned a cDNA encoding a novel protein (PAL31) predominantly expressed in the fetal rat brain by differential display. PAL31 contains leucine-rich repeat domains, a highly acidic region and a putative nuclear localization signal. PAL31 has 50-70% similarity to SSP29, APRIL, LANP, PHAP I, and PP32. Expression of PAL31 mRNA in the brain was high during the fetal period and decreased after birth. Immunohistochemical studies showed that PAL31 is expressed in the entire embryonic brain, whereas… CONTINUE READING

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