PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion

@inproceedings{Wang2015PAK1RR,
  title={PAK1 regulates RUFY3-mediated gastric cancer cell migration and invasion},
  author={Guoli Wang and Qilin Zhang and Y Song and Xiao-hua Wang and Qiqiang Guo and Jin Hai Zhang and Jia-yi Li and Ying-ying Han and Zhigang Miao and Fuqing Li},
  booktitle={Cell Death and Disease},
  year={2015}
}
  • Guoli Wang, Qilin Zhang, +7 authors Fuqing Li
  • Published in Cell Death and Disease 2015
  • Biology, Medicine
  • Actin protrusion at the cell periphery is central to the formation of invadopodia during tumor cell migration and invasion. Although RUFY3 (RUN and FYVE domain containing 3)/SINGAR1 (single axon-related1)/RIPX (Rap2 interacting protein X) has an important role in neuronal development, its pathophysiologic role and relevance to cancer are still largely unknown. The purpose of this study was to elucidate the molecular mechanisms by which RUFY3 involves in gastric cancer cell migration and… CONTINUE READING

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