PAK1 as a therapeutic target.

@article{Kichina2010PAK1AA,
  title={PAK1 as a therapeutic target.},
  author={Julia V. Kichina and Anna Goc and Belal Al-Husein and Payaningal R Somanath and Eugene S. Kandel},
  journal={Expert opinion on therapeutic targets},
  year={2010},
  volume={14 7},
  pages={
          703-25
        }
}
IMPORTANCE OF THE FIELD P21-activated kinases (PAKs) are involved in multiple signal transduction pathways in mammalian cells. PAKs, and PAK1 in particular, play a role in such disorders as cancer, mental retardation and allergy. Cell motility, survival and proliferation, the organization and function of cytoskeleton and extracellular matrix, transcription and translation are among the processes affected by PAK1. AREAS COVERED IN THIS REVIEW We discuss the mechanisms that control PAK1… CONTINUE READING
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