PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects

Abstract

Deficits in auditory processing are among the best documented endophenotypes in schizophrenia, possibly due to loss of excitatory synaptic connections. Dendritic spines, the principal post-synaptic target of excitatory projections, are reduced in schizophrenia. p21-activated kinase 1 (PAK1) regulates both the actin cytoskeleton and dendritic spine density… (More)
DOI: 10.1371/journal.pone.0059458

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