PAK-PIX interactions regulate adhesion dynamics and membrane protrusion to control neurite outgrowth.

Abstract

The roles of P21-activated kinase (PAK) in the regulation of axon outgrowth downstream of extracellular matrix (ECM) proteins are poorly understood. Here we show that PAK1-3 and PIX are expressed in the developing spinal cord and differentially localize to point contacts and filopodial tips within motile growth cones. Using a specific interfering peptide… (More)
DOI: 10.1242/jcs.112607

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