PAI-1 transcriptional regulation during the G0 --> G1 transition in human epidermal keratinocytes.

@article{Qi2006PAI1TR,
  title={PAI-1 transcriptional regulation during the G0 --> G1 transition in human epidermal keratinocytes.},
  author={Li Ping Qi and Rosalie R Allen and Qi Lu and Craig E. Higgins and Rosemarie Garone and Lisa F Staiano-Coico and Paul J. Higgins},
  journal={Journal of cellular biochemistry},
  year={2006},
  volume={99 2},
  pages={495-507}
}
Plasminogen activator inhibitor type-1 (PAI-1) is the major negative regulator of the plasmin-dependent pericellular proteolytic cascade. PAI-1 gene expression is normally growth state regulated but frequently elevated in chronic fibroproliferative and neoplastic diseases affecting both stromal restructuring and cellular migratory activities. Kinetic modeling of cell cycle transit in synchronized human keratinocytes (HaCaT cells) indicated that PAI-1 transcription occurred early after serum… CONTINUE READING
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