PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair.

@article{Providence2004PAI1EI,
  title={PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair.},
  author={Kirwin M. Providence and Paul J. Higgins},
  journal={Journal of cellular physiology},
  year={2004},
  volume={200 2},
  pages={
          297-308
        }
}
Several proteases and their specific inhibitors modulate the interdependent processes of cell migration and matrix proteolysis as part of the global program of trauma repair. Expression of plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor (SERPIN) important in the control of barrier proteolysis and cell-to-matrix adhesion, for example, is spatially-temporally regulated following epithelial denudation injury in vitro as well as in vivo. PAI-1 mRNA/protein synthesis was… CONTINUE READING
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