PAI-1 and Diabetes: A Journey From the Bench to the Bedside

  title={PAI-1 and Diabetes: A Journey From the Bench to the Bedside},
  author={David J. Schneider and B. E. Sobel},
  booktitle={Diabetes care},
D iabetologists have been well aware since the seminal work ofHimsworth (1) in the 1930s that type 2 (insulin resistant) and type 1 (insulin deficient) diabetes were distinct entities with different pathophysiological bases. They have been aware for some time that type 2 diabetes is associated with resistance of tissues such as muscle and liver to the biological effects of insulin. Furthermore, they knew that type 2 diabetes per se and insulin resistance could both predispose to an increased… CONTINUE READING
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