PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition.

@article{Webber1997PAFinducedSH,
  title={PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition.},
  author={S. Webber and A. Kitt and E. Yurdakoş and J. Widdicombe},
  journal={Pulmonary pharmacology \& therapeutics},
  year={1997},
  volume={10 3},
  pages={
          157-66
        }
}
Both PAF (10 microM) and bradykinin (0.1-10 microM) increased lysozyme (from submucosal gland serous cells (+138 and +45% for PAF, 10 microM, and bradykinin, 1 microM, respectively) and albumin (mainly active epithelial transport; +387 and +108%) outputs into the ferret tracheal lumen in vitro and reduced the negativity of the potential difference (PD: -33 and -17%) across the trachea. Since PAF can cause bronchial smooth muscle hyperresponsiveness, we tested whether these effects were… Expand
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