PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation.

  title={PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation.},
  author={Hae-Yun Jung and Sohee Jun and Moonsup Lee and Han-Cheon Kim and Xin Wang and Hong Bo Ji and Pierre D. McCrea and Jae-il Park},
  journal={Molecular cell},
  volume={52 2},
Fine control of Wnt signaling is essential for various cellular and developmental decision-making processes. However, deregulation of Wnt signaling leads to pathological consequences, one of which is cancer. Here, we identify a function of PAF, a component of translesion DNA synthesis, in modulating Wnt signaling. PAF is specifically overexpressed in colon cancer cells and intestinal stem cells and is required for colon cancer cell proliferation. In Xenopus laevis, ventrovegetal expression of… CONTINUE READING