PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15).

@article{Larsen1990PADGEMdependentAO,
  title={PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15).},
  author={Elise Larsen and Theresa M. Palabrica and Susan A. Sajer and Gary E. Gilbert and Denisa D Wagner and Barbara C. Furie},
  journal={Cell},
  year={1990},
  volume={63 3},
  pages={467-74}
}
PADGEM (platelet activation-dependent granule-external membrane protein) is a leukocyte receptor of activated platelets that mediates cellular adhesion of platelets to neutrophils and monocytes. To identify the natural ligand on neutrophils and monocytes that interacts with PADGEM, we have evaluated anti-leukocyte antibodies for their ability to block leukocyte-PADGEM binding. Only anti-CD15 antibodies were able to inhibit the binding of neutrophils, monocytes, HL60 cells, and U937 cells to… CONTINUE READING

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