PACE trial authors continue to ignore their own null effect

@article{Vink2017PACETA,
  title={PACE trial authors continue to ignore their own null effect},
  author={Mark Vink},
  journal={Journal of Health Psychology},
  year={2017},
  volume={22},
  pages={1134 - 1140}
}
  • M. Vink
  • Published 27 April 2017
  • Psychology, Medicine
  • Journal of Health Psychology
Protocols and outcomes for the PACE trial were changed after the start of the trial. These changes made substantial differences, leading to exaggerated claims for the efficacy of cognitive behavior therapy and graded exercise therapy in myalgic encephalomyelitis/chronic fatigue syndrome. The small, self-reported improvements in subjective measures cannot be used to say the interventions are effective, particularly in light of the absence of objective improvement. Geraghty’s criticism of the… 
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References

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TLDR
In this extraordinary case, patients discovered that the treatments tested had much lower efficacy after an information tribunal ordered the release of data from the PACE trial to a patient who had requested access using a freedom of information request.
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Analysis of the individual participant PACE trial data has shown that CBT and GET are ineffective and (potentially) harmful, which invalidates the assumption and opinion-based biopsychosocial model.
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