PACAP38 modulates activity of NMDA receptors in cultured chick cortical neurons.

@article{Liu1997PACAP38MA,
  title={PACAP38 modulates activity of NMDA receptors in cultured chick cortical neurons.},
  author={Guo Jun Liu and Barry W. Madsen},
  journal={Journal of neurophysiology},
  year={1997},
  volume={78 4},
  pages={2231-4}
}
The outside-out recording mode of the patch-clamp technique was used to study modulatory effects of pituitary adenylate cyclase-activating polypeptide (PACAP38) on N-methyl--aspartate (NMDA) receptor activity in cultured chick cortical neurons. Biphasic concentration-dependent effects of PACAP38 on channel opening frequency induced by NMDA (20 microM) and glycine (1 microM) were found, with low concentrations (0.5-2 nM) of PACAP38 increasing activity and higher concentrations (10-1,000 nM… CONTINUE READING