PACAP potentiates L-type calcium channel conductance in suprachiasmatic nucleus neurons by activating the MAPK pathway.

@article{Dziema2002PACAPPL,
  title={PACAP potentiates L-type calcium channel conductance in suprachiasmatic nucleus neurons by activating the MAPK pathway.},
  author={Heather L. Dziema and Karl Obrietan},
  journal={Journal of neurophysiology},
  year={2002},
  volume={88 3},
  pages={1374-86}
}
The endogenous pacemaker activity of the suprachiasmatic nuclei (SCN; the master clock in mammals) is regulated by photic information relayed from the retina to the SCN via the retinohypothalamic tract (RHT). Recent work has revealed that glutamate and pituitary adenylate cyclase-activating polypeptide (PACAP) are stored in RHT nerve terminals and function in a coordinated manner to regulate clock timing. To address this interaction on a cellular level, Fura-2 Ca(2+) digital imaging was… CONTINUE READING
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PACAP modulates glutamatergic signaling in the suprachiasmatic nuclei via the MAPK pathway

  • K. OBRIETAN
  • Soc Neurosci Abst 76:
  • 2000
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