PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP.

@article{Mei2004PACAPID,
  title={PACAP inhibits delayed rectifier potassium current via a cAMP/PKA transduction pathway: evidence for the involvement of I k in the anti-apoptotic action of PACAP.},
  author={Yongfeng Mei and David Vaudry and Magali Basille and H{\'e}l{\`e}ne Castel and Alain Fournier and Hubert Vaudry and Bruno J. Gonzalez},
  journal={The European journal of neuroscience},
  year={2004},
  volume={19 6},
  pages={1446-58}
}
Abstract Activation of potassium (K(+)) currents plays a critical role in the control of programmed cell death. Because pituitary adenylate cyclase-activating polypeptide (PACAP) has been shown to inhibit the apoptotic cascade in the cerebellar cortex during development, we have investigated the effect of PACAP on K(+) currents in cultured cerebellar granule cells using the patch-clamp technique in the whole-cell configuration. Two types of outward K(+) currents, a transient K(+) current (I(A… CONTINUE READING

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