PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus.

@article{Nakata2004PACAPDM,
  title={PACAP deficient mice display reduced carbohydrate intake and PACAP activates NPY-containing neurons in the rat hypothalamic arcuate nucleus.},
  author={Masanori Nakata and Daisuke Kohno and Norihito Shintani and Yuriko Nemoto and Hitoshi Hashimoto and A. Ramesha Baba and Toshihiko Yada},
  journal={Neuroscience letters},
  year={2004},
  volume={370 2-3},
  pages={252-6}
}
Pituitary adenylate cyclase-activating polypeptide (PACAP) potentiates both insulin release from islets and insulin action in adipocytes. Therefore, this peptide is considered a regulator of glucose homeostasis. PACAP and its receptors are localized not only in the peripheral tissues but in the central nervous system. The present study examined whether PACAP regulates the feeding behavior and the activity of neurons in the hypothalamic arcuate nucleus (ARC), a feeding center. Food intake was… CONTINUE READING

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