PACAP and glutamate are co-stored in the retinohypothalamic tract.

  title={PACAP and glutamate are co-stored in the retinohypothalamic tract.},
  author={Jens Hannibal and Morten M\oller and Ole Petter Ottersen and Jan Fahrenkrug},
  journal={The Journal of comparative neurology},
  volume={418 2},
The retinohypothalamic tract (RHT) relays photic information from the eyes to the suprachiasmatic nucleus (SCN). Activation of this pathway plays a role in adjusting circadian timing to the light/dark environment. Two transmitters, glutamate and pituitary adenylate cyclase activating polypeptide (PACAP) having phase shifting capacity during the night and day, respectively, are located in the RHT. Using double staining immunohistochemistry at the light and electron microscopic level, we showed… CONTINUE READING


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