PACAP and VIP signaling in chondrogenesis and osteogenesis

@article{Juhsz2015PACAPAV,
  title={PACAP and VIP signaling in chondrogenesis and osteogenesis},
  author={Tam{\'a}s Juh{\'a}sz and Solveig Lind Helgadottir and Andrea Tamas and Dora Reglodi and R{\'o}za Z{\'a}k{\'a}ny},
  journal={Peptides},
  year={2015},
  volume={66},
  pages={51-57}
}

Figures from this paper

Role of PACAP/VIP in Bone and Joint Physiology and Pathophysiology

The direct effects of PACAP/VIP on skeletal tissues, their immunoregulatory properties, and their pivotal importance in nociception and peripheral/central sensitization all have potential clinical relevance.

Lack of Pituitary Adenylate Cyclase–Activating Polypeptide (PACAP) Disturbs Callus Formation

The results indicate that PACAP KO mice show various signs of disturbed bone healing and suggest PACAP compensatory and fine tuning effects in proper bone regeneration.

Signalling Alterations in Bones of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Gene Deficient Mice

The results show that lack of PACAP influences molecular and biomechanical properties of bone matrix, activating various signalling cascade changes in a compensatory fashion, and the increased fragility ofPACAP KO femur further supports the role of endogenous PACAP in in vivo bone formation.

Ameliorative Effects of PACAP against Cartilage Degeneration. Morphological, Immunohistochemical and Biochemical Evidence from in Vivo and in Vitro Models of Rat Osteoarthritis

A potential role for PACAP as a chondroprotective agent for the treatment of OA is supported and changes in PACAP distribution in cartilage, or its concentration in synovial fluid, were assessed, suggesting an anti-inflammatory effect.

Peripheral Nerve Fibers and Their Neurotransmitters in Osteoarthritis Pathology

It is evident that sensory and sympathetic neurotransmitters have crucial trophic effects which are critical for joint tissue and bone homeostasis and seem to play a role in pathogenesis of priori degenerative joint disorders such as osteoarthritis.

Do Neuroendocrine Peptides and Their Receptors Qualify as Novel Therapeutic Targets in Osteoarthritis?

It appears more and more likely that the anabolic effects of these neuroendocrine peptides or their respective receptor agonists/antagonists may be exploited for the treatment of patients with inflammatory and degenerative joint diseases in the future.

Age-related alterations of articular cartilage in pituitary adenylate cyclase–activating polypeptide (PACAP) gene–deficient mice

The results suggest that loss of PACAP signaling results in dysregulation of cartilage matrix composition and may transform articular cartilage in a way that it becomes more prone to degenerate.

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Reduces Oxidative and Mechanical Stress-Evoked Matrix Degradation in Chondrifying Cell Cultures

Application of PACAP can help to preserve the integrity of the newly synthetized cartilage matrix via signaling mechanisms, which ultimately inhibit the activity of matrix destroying enzymes under cellular stress, suggesting the prospect that application ofPACAP can ameliorate articular cartilage destruction in joint diseases.

Macrophage Polarization and Alveolar Bone Healing Outcome: Despite a Significant M2 Polarizing Effect, VIP and PACAP Treatments Present a Minor Impact in Alveolar Bone Healing in Homeostatic Conditions

While both VIP and PACAP treatments presented a significant immunomodulatory effect with potential for increased healing, no major changes were observed in bone healing outcome, suggesting that the signals required for bone healing under homeostatic conditions are already optimal, and additional signals do not improve an already optimal process.

VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts

The results point to novel OA therapies based on the use of neuropeptides, since VIP and CRF are able to stop the first critical step, the loss of cartilage aggrecan and the ECM destabilization during joint degradation.

References

SHOWING 1-10 OF 102 REFERENCES

A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration

The interactions between MAPK and Wnt signaling with respect to cartilage-related diseases such as osteoarthritis are discussed and potential therapeutic targets for disease treatments are explored.

The control of chondrogenesis

This work has revealed novel roles for mediators such as GADD45β, transcription factors of the Dlx, bHLH, leucine zipper, and AP‐1 families, and the Wnt/β‐catenin pathway that interact at different stages during chondrogenesis.

The neuropeptide VIP regulates the expression of osteoclastogenic factors in osteoblasts

It is demonstrated that activation of VPAC2 receptors in osteoblasts enhances the RANKL/OPG ratio by mechanisms mediated by cyclic AMP and ERK pathways suggesting an important role for VIP in bone remodeling.

Distinct VEGF Functions During Bone Development and Homeostasis

  • Yanqiu LiuB. Olsen
  • Biology, Medicine
    Archivum Immunologiae et Therapiae Experimentalis
  • 2014
A better understanding of the intracellular mechanisms by which VEGF regulates osteoblastic and adipogenic differentiation may lead to the identification of new targets for therapies to prevent osteoporotic bone loss.

Effects of Neuropeptides and Mechanical Loading on Bone Cell Resorption in Vitro

The results suggest that neuropeptides CGRP and VIP have an important role in suppressing bone resorptive activities through RANKL/OPG pathway, similar to mechanical loading.

Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Signalling Exerts Chondrogenesis Promoting and Protecting Effects: Implication of Calcineurin as a Downstream Target

It is proposed that calcineurin is a downstream target of PACAP signalling in differentiating chondrocytes either in normal or pathophysiological conditions and may promote cartilage regeneration during degenerative diseases of articular cartilage.

Bone tissue remodeling and development: focus on matrix metalloproteinase functions.

...