PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression.

@article{Aubert2006PACAPAC,
  title={PACAP and C2-ceramide generate different AP-1 complexes through a MAP-kinase-dependent pathway: involvement of c-Fos in PACAP-induced Bcl-2 expression.},
  author={Nicolas Aubert and Anthony Falluel-Morel and David Vaudry and Xavier Xifr{\'o} and Jos{\'e} Rodr{\'i}guez-{\'A}lvarez and C{\'e}cile Fisch and St{\'e}phane de Jouffrey and Jean-François Lebigot and Alain Fournier and Hubert Vaudry and Bruno J. Gonzalez},
  journal={Journal of neurochemistry},
  year={2006},
  volume={99 4},
  pages={1237-50}
}
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) inhibits C2-ceramide-induced cell death through blockade of the mitochondrial apoptotic pathway in rat cerebellar granule neurones. However, the gene induction processes and transcription factors involved in the anti-apoptotic effect of PACAP remain unknown. Here, we show that PACAP and C2-ceramide activate activator protein-1 (AP-1) DNA binding in a dose- and time-dependent manner, but generate different AP-1 dimers… CONTINUE READING