PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia

@article{Khodai2018PACAPNI,
  title={PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia},
  author={Tansi Khodai and N. Nunn and A. Worth and C. Feetham and M. D. Belle and H. Piggins and S. Luckman},
  journal={Frontiers in Endocrinology},
  year={2018},
  volume={9}
}
Background: Glucose-sensing neurons are located in several parts of the brain, but are concentrated in the ventromedial nucleus of the hypothalamus (VMH). The importance of these VMH neurons in glucose homeostasis is well-established, however, little is known about their individual identity. In the present study, we identified a distinct glucose-sensing population in the VMH and explored its place in the glucose-regulatory network. Methods: Using patch-clamp electrophysiology on Pacap-cre::EYFP… Expand
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References

SHOWING 1-10 OF 43 REFERENCES
Functional identification of a neurocircuit regulating blood glucose
  • 70
  • Highly Influential
  • PDF
PACAP Neurons in the Hypothalamic Ventromedial Nucleus Are Targets of Central Leptin Signaling
  • 68
  • PDF
Glucose and Osmosensitive Neurones of the Rat Hypothalamus
  • 573
Ventromedial Hypothalamic Nitric Oxide Production Is Necessary for Hypoglycemia Detection and Counterregulation
  • 77
  • PDF
Prior hypoglycemia enhances glucose responsiveness in some ventromedial hypothalamic glucosensing neurons.
  • Ling Kang, N. Sanders, +4 authors B. Levin
  • Psychology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 2008
  • 37
  • PDF
Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing.
  • 176
  • PDF
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2
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5
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