PACAP-Deficient Mice Exhibit Light Parameter–Dependent Abnormalities on Nonvisual Photoreception and Early Activity Onset

@inproceedings{Kawaguchi2010PACAPDeficientME,
  title={PACAP-Deficient Mice Exhibit Light Parameter–Dependent Abnormalities on Nonvisual Photoreception and Early Activity Onset},
  author={Chihiro Kawaguchi and Yasushi Isojima and Norihito Shintani and Michiyoshi Hatanaka and Xiaohong Guo and Nobuaki Okumura and Katsuya Nagai and Hitoshi Hashimoto and A. Ramesha Baba},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The photopigment melanopsin has been suggested to act as a dominant photoreceptor in nonvisual photoreception including resetting of the circadian clock (entrainment), direct tuning or masking of vital status (activity, sleep/wake cycles, etc.), and the pupillary light reflex (PLR). Pituitary adenylate cyclase-activating polypeptide (PACAP) is exclusively coexpressed with melanopsin in a small subset of retinal ganglion cells and is predicted to be involved extensively in these… CONTINUE READING

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