PACAP: a master regulator of neuroendocrine stress circuits and the cellular stress response.

  title={PACAP: a master regulator of neuroendocrine stress circuits and the cellular stress response.},
  author={Nikolas Stroth and Yvonne Holighaus and Djida Ait-Ali and Lee E. Eiden},
  journal={Annals of the New York Academy of Sciences},
The neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) is released from stress-transducing neurons. It exerts postsynaptic effects required to complete the hypothalamo-pituitary-adrenocortical (HPA) and hypothalamo-sympatho-adrenal (HSA) circuits activated by psychogenic and metabolic stressors. Upon activation of these circuits, PACAP-responsive (in cell culture models) and PACAP-dependent (in vivo) transcriptomic responses in the adrenal gland, hypothalamus, and pituitary… CONTINUE READING


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